解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases. Promising therapies for PD still need to be explored. Immune dysfunction has been found to be involved in PD pathogenesis. Here, a novel immunosuppressor, (5R)-5-hydroxytriptolide (LLDT8), was used to treat 6-hydroxydopamine (6-...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.0929
更新日期:2017-02-01 00:00:00
abstract::Muscle power is a strong predictor of functional status in the elderly population and is required to perform different daily activities. To compare the effects of different weekly training frequencies on muscle power and muscle quality induced by concurrent training (resistance + aerobic) in previously trained elderly...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.0504
更新日期:2016-12-01 00:00:00
abstract::A promising strategy for the prevention of Alzheimer's disease (AD) is the identification of age-related changes that place the brain at risk for the disease. Additionally, AD is associated with chronic dehydration, and one of the significant changes that are known to result in metabolic dysfunction is an increase in ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.0323
更新日期:2016-10-01 00:00:00
abstract::Cisplatin is a commonly used chemotherapeutic drug, used for the treatment of malignant ovarian cancer, but acquired resistance limits its application. There is therefore an overwhelming need to understand the mechanism of cisplatin resistance in ovarian cancer, that is, ovarian cancer cells are insensitive to cisplat...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.0118
更新日期:2016-05-27 00:00:00
abstract::Hypoxia is an environmental stress at high altitude and underground conditions but it is also present in many chronic age-related diseases, where blood flow into tissues is impaired. The oxygen-sensing system stimulates gene expression protecting tissues against hypoxic insults. Hypoxia stabilizes the expression of hy...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2015.0929
更新日期:2016-03-15 00:00:00
abstract::Stroke is the second leading cause of death worldwide. The prognostic influence of body temperature on acute stroke in patients has been recently reported; however, hypothermia has confounded experimental results in animal stroke models. This work aimed to investigate how body temperature could prognose stroke severit...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2015.0906
更新日期:2016-01-02 00:00:00
abstract::Cortical atrophy, neuronal loss, beta-amyloid deposition, neuritic plaques, and neurofibrillary tangles are neuropathological key features in the Alzheimer's disease (AD). Antibodies against beta-amyloid, neurotransmitters, microvascular endothelium components and microglial cells have been detected in AD serum sugges...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2015.1124
更新日期:2015-11-24 00:00:00
abstract::The relationship between CYP17A1 genetic polymorphisms and essential hypertension (EH) remains unclear. The aim of this study was to investigate the association of CYP17A1 genetic polymorphisms with EH in Han and Uighur populations in China. A Han population including 558 people (270 EH patients and 288 controls) and ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2015.0505
更新日期:2015-11-17 00:00:00
abstract::Dopamine (DA) is one of the major neurotransmitters and participates in a number of functions such as motor coordination, emotions, memory, reward mechanism, neuroendocrine regulation etc. DA exerts its effects through five DA receptors that are subdivided in 2 families: D1-like DA receptors (D1 and D5) and the D2-lik...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2015.0330
更新日期:2015-10-01 00:00:00
abstract::Alzheimer's disease (AD), the major cause of dementia among the elderly world-wide, manifests in familial and sporadic forms, and the latter variety accounts for the majority of the patients affected by this disease. The etiopathogenesis of sporadic AD is complex and uncertain. The autopsy studies of AD brain have pro...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.002
更新日期:2015-08-01 00:00:00
abstract::Superoxide is a precursor of many free radicals and reactive oxygen species (ROS) in biological systems. It has been shown that superoxide regulates major epigenetic processes of DNA methylation, histone methylation, and histone acetylation. We suggested that superoxide, being a radical anion and a strong nucleophile,...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0924
更新日期:2015-06-01 00:00:00
abstract::As one of the leading causes of death around the world, suicide is a global public health threat. In the Chinese population, suicides constitute one-fifth of all recorded suicides in the world. Despite the factual data on suicide rates, the understanding of various causal factors behind suicide, including risk and pro...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0223
更新日期:2015-03-10 00:00:00
abstract::It is currently well established that the immune system is activated in response to transient or focal cerebral ischemia. This acute immune activation occurs in response to damage, and injury, to components of the neurovascular unit and is mediated by the innate and adaptive arms of the immune response. The initial im...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500307
更新日期:2014-10-01 00:00:00
abstract::With an increased life expectancy in humans and thus an increase in the number of the elderly population, the frequency of hip fractures will rise as well. Aside from a higher incidence, hip fractures in a geriatric population is a significant problem due to the possible onset of severe and in some cases dramatic comp...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500177
更新日期:2014-06-01 00:00:00
abstract::Age-related hearing loss (ARHL), a degenerative disorder characterized by age-dependent progressive increase in the threshold of auditory sensitivity, affects 40% of people over the age of 65, and it has emerged as an important social and public health problem. Various factors, including genetic and environmental comp...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500150
更新日期:2014-04-01 00:00:00
abstract::Healthcare-associated pneumonia (HCAP) is a new concept of pneumonia proposed by the American Thoracic Society/Infectious Diseases Society of America in 2005. This category is located between community-acquired pneumonia and hospital-acquired pneumonia with respect to the characteristics of the causative pathogens and...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0127
更新日期:2014-02-08 00:00:00
abstract::Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induc...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500394
更新日期:2013-12-17 00:00:00
abstract::The TOR (target of rapamycin) pathway has been convincingly shown to promote aging in various model organisms. In mice, inhibiting mTOR (mammalian TOR) by rapamycin treatment later in life can significantly extend lifespan and mitigate multiple age-related diseases. However, the underlying mechanisms are poorly unders...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500263
更新日期:2013-12-05 00:00:00
abstract::Cardiovascular disease is one of the most common causes of death worldwide and the most usual in the western populations. Although it affects both sexes, it is more frequent in males in whom it shortens the average life expectancy. This difference has been attributed to the negative effects of testosterone; however, r...
journal_title:Aging and disease
pub_type:
doi:10.14336/AD.2013.0400381
更新日期:2013-10-07 00:00:00
abstract::Alzheimer disease (AD) is the most common dementing illness. Metabolic defects in the brain with aging contribute to the pathogenesis of AD. These changes can be found systematically and thus can be used as potential biomarkers. Erythrocytes (RBCs) are passive "reporter cells" that are not well studied in AD. In the p...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2013.0400244
更新日期:2013-10-01 00:00:00
abstract::Alzheimer's disease (AD) and vascular dementia (VAD) are the major forms of dementia affecting elderly people, in which the levels of many metabolites are altered in cerebrospinal fluid (CSF) and serum. These metabolites could be risk factors or potential biomarkers, but the significance of some of these are not clear...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2013-03-07 00:00:00
abstract::Age related bone loss predisposes adults to osteoporosis. This is especially true for individuals with spinal cord injury (SCI). The effects of decreased bone loading with older age and paralysis significantly contribute to decreased bone mass and increased risk for fragility fractures. Loading bone via volitional mus...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2013-02-07 00:00:00
abstract::Multiple cues from the environment of our indirect and immediate ancestors, which often persist throughout the prenatal period and adulthood, are shaping our phenotypes through either direct, parent-to-child influences, or transgenerational inheritance. These effects are due to gene-environment interactions, which are...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-12-01 00:00:00
abstract::Longstanding immunological dogma holds that flexible immune recognition, which forms the mechanistic basis of adaptive immunity, is strictly confined to the lymphocyte lineage. In higher vertebrates, flexible immune recognition is represented by recombinatorial antigen receptors of enormous diversity known as immunogl...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-10-01 00:00:00
abstract::The serotonin receptor 2A gene polymorphism is associated with attentional processes in schizophrenia. However, the specificity of the underlying cognitive constructs affected within this domain requires further elucidation. We carried out the first investigation of whether the TC/CC genotype of the 5-HT2A T102C polym...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-08-01 00:00:00
abstract::Melatonin is a pleiotropically acting regulator molecule, which influences numerous physiological functions. Its secretion by the pineal gland progressively declines by age. Strong reductions of circulating melatonin are also observed in numerous disorders and diseases, including Alzheimer's disease, various other neu...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-04-01 00:00:00
abstract::Studies comparing chronologically "young" versus "old" humans document age-related decline of classical immunological functions. However, older adults aged ≥65 years have very heterogeneous health phenotypes. A significant number of them are functionally independent and are surviving well into their 8(th)-11(th) decad...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-02-01 00:00:00
abstract::The immune system declines with aging, leading to an increased susceptibility to infections and higher incidence and progression of autoimmune phenomena and neoplasia. Down syndrome prematurely shows clinical manifestations that are normally seen with aging. This review provides a concise overview of abnormalities in ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2011-12-01 00:00:00
abstract::Aging is associated with a variety of changes to immune responsiveness. Reduced protection against infection, reduced responses to vaccination and increased risk of autoimmunity are all hallmarks of advanced age. Here we consider how changes in the expression of regulatory receptors on the T cell surface contribute to...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2011-10-01 00:00:00
abstract::Neurogenesis in the hippocampal dentate gyrus persists throughout the lifespan of mammals, however, the rate of neurogenesis decreases as the animal ages. Although seizures increase neurogenesis in young adult brains, this relationship has not been shown in aged animals. Using doublecortin (DCX) immunocytochemistry, t...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2011-08-01 00:00:00
abstract::Advances in pharmacological treatment and effective early myocardial revascularization have -in recent years- led to improved clinical outcomes in patients with acute myocardial infarction (AMI). However, it has been suggested that compared to younger subjects, elderly AMI patients are less likely to receive evidence-...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2011-04-01 00:00:00
abstract::Aging is associated with myriad changes in behavioral performance and brain structure and function. Given this complex interplay of brain and behavior, two streams of findings are reviewed here that show that aging is generally associated with dedifferentiated neural processes, and also changes in functional connectiv...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::A temporal framework linking circadian rhythms and clocks to aging rates identifies a specific window of target of rapamycin (TOR) signaling associated with growth hormone (GH) and insulin-like growth factor (IGF-1) (largely exclusive of insulin) in early sleep. IGF-1 signaling is released by growth hormone secretory ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2010-10-01 00:00:00
abstract::Healthy aged individuals are more likely to suffer profound memory impairments following a challenging life event such as a severe bacterial infection, surgery, or an intense psychological stressor, than are younger adults. These peripheral challenges are capable of producing a neuroinflammatory response, (e.g., incre...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00